Those in Danville, near Lexington, also hope to benefit from the debate.
Streets have been repaved, flowers planted and new signs put up around the town of 16-thousand.
The Centre College's auditorium is being filled with all kinds of equipment. One bar even made new cocktails named for Ryan and Biden, while stores have stocked up on politically-themed merchandise.
The town also hosted a Vice Presidential Debate in 2000, between Dick Cheney and Joe Lieberman.
Eyewitness News will have a crew in Danville for Thursday's debate.