The debate has mushroomed in importance since Mitt Romney's strong showing in the first Presidential face-off.
This time, it's the Obama team looking to put the brakes his challenger's momentum. The V.P. showdown at Centre College in Danville, Kentucky, matches up two skilled politicians with strong policy credentials and very different styles.
It's 69-year-old Biden's folksy appeal and solid Vice Presidential portfolio vs. 42-year-old Ryan's intensity and extensive knowledge of the federal budget and economy from 14 years in Congress.
Like the second installment in a miniseries, it will help to shape the campaign narrative until Romney and Obama themselves meet up again next Tuesday.
Eyewitness News will have a crew in Danville and will bring you more on the debate throughout the day.