Large crowds are expected to brave the cold in Indianapolis to see Pence take the oath.
Pence replaces Mitch Daniels, who has served for the past eight years.
The ceremony starts at 10:00a.m. Central Time, with the oath being administered about half-way through. His innauguration address will follow.
Eyewitness News has a crew in Indy, and we will have complete coverage of the ceremony throughout the day.